Sunday, May 31, 2009

mutually exclusive rad scenarios?



Claudia Wiese, Eloϊse Dray, Torsten Groesser, Joseph San Filippo, Idina Shi, David W. Collins, Miaw-Sheue Tsai, Gareth Williams, Bjorn Rydberg, Patrick Sung, and David Schild. 2007. Promotion of homologous recombination and genomic stability by RAD51AP1 via RAD51 recombinase enhancement. Molecular Cell

As an alternative to David Goodsell's triple helix model (see below) Rad51 may instead encircle the bound template and recipient DNA strands, as gene conversion takes place, leaving the donor's complementary strand (displacement loop) out..


A similar, earlier view on rad51 and rad54 nucleoprotein filament and D-loops:

The development and regulation of gene repair

Li Liu, Hetal Parekh-Olmedo & Eric B. Kmiec

Nature Reviews Genetics 4679-689

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