Monday, May 11, 2009

1st research methods class + feedback

After presenting my visual question, and current state of research in class today, a few very interesting suggestions were made:

- the possibility of using a random (or nearly, depending on how random the selection of pseudogene sequences is; I think there may be evidence that pseudogenes nearer to the VJ segment are preferentially incorporated) formula / generating code (in maya?) to select pseudogene base pairs for gene conversion
- then I could show many b cells undergoing gene conversion simultaneously, but producing different converted genes depending on what pseudogene elements were selected by the formula / generator
- I could extend this further by then showing the differences in protein structure between b cells after gene conversion (i.e. after transcription and translation), and colouring the mutated/converted amino  acids so that they stand out?
- I wonder if it would be possible to have a 'program / code' that could incorporate the base pairs, and another that could take base pairs and 'translate' these into amino acid sequences (i.e. I would have many long strings of dna and want to 'magically' convert these into different amino acids at the level of the 3D animation, not at the pre-rendering stage when I could use a table or amino acid generator from the internet)

- the idea of periodically using flattened, 2D animations, like the Engelward Lab's, to clarify otherwise complex DNA nicking, inserting, winding and unwinding processes
- this is along the same lines as using sliding stills
- and other non-photorealistic / more schematic visual approaches

- further research direction: justifying my cinematic decisions (i.e. why is a 3D animation beneficial in depicting gene conversion)


Note on the idea of the formula/generator:  its primary purpose would be to simplify the rendering process

No comments:

Post a Comment