I'm in the process of colourizing, and finding a good balance between:
- interesting narration (that incorporates many smaller narrative questions and answers, which accumulate and lead up to the final message of the film)
- eliminating confusing or ambiguous visualizations and plot twists (that would detract from viewer interest and understanding)
- finding a way to visually unify the various scales (and rendering styles) used in the mini story arcs (i.e. the intro [zoom in] from the organism down to a cellular scale, the more 'schematic' gene rearrangement segment, the tissue/cellular level visualization of bursal follicles, another schematic approach in gene conversion, and the final zoom out showing the repercussions/happy ending of the creation of a diverse b-cell repertoire) ... but at the same time use a variety of scene compositions and dynamic shots
- keep everything as scientifically accurate as possible (--> choosing words carefully in the script)
- prioritize time logically: i.e. don't go into too much detail in one topic, and neglect another..
- in a similar vein: I'm looking forward to finding creative solutions, outside of rendering everything in 3D, to depict some of these processes (I think a lot of the cellular and tissue landscapes will be done in maya, and the molecular segments may be done using an AfterEffects, animatic approach, and I may also use live action footage if there isn't time to render a chick)



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