Thursday, September 24, 2009

A Photometaphor of Gene Conversion..



There once was a rocky shore by a lake.

And on that shore lived a pile of rocks. But all was not well with this accumulation of stones. It was sad.


It would watch the various, curious creatures flow in and out of its part of the beach, each with its own busy life and unique purpose..


One day, the rock pile realized the source of its unhappiness. It was so disorganized!


Then along came some helpful hands! They began poking and rearranging the pile of rocks..



And went to great lengths maneuvering new stones out of nooks and crannies along the beach to add to the pile..



Every new addition was placed on the growing stack precisely, and deliberately. 



It should also be noted how unique every individual rock was; a little examination would uncover sedimentary stories of deep time, ancient oceans, and evolutionary plots long buried..



Gradually, the haphazard accumulation of stones metamorphosed into a recognizable structure.. 



An inukshuk! 



Legend has it that inukshuks point the way to paths leading weary travelers in the direction of salvation..



Or in this case, a cool respite on a sunny day by the beach.



The end.


Explanation: 
-Stone Pile is the Immunoglobulin Gene Locus
-Each stone represents a sequence of DNA, and the rocks scavenged are analogous to pseudogenes
-Hands are proteins
- Pointing the way to DQ = immunoglobulin gene is the blueprint/encoded message leading to an Ig protein

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